Coenzyme Q10 (CoQ10): What You Need To Know
On this page:
- What’s the Bottom Line?
- What Is CoQ10 and Why Is It Important?
- What the Science Says About Effectiveness of CoQ10
- What the Science Says About Safety and Side Effects of CoQ10
- National Institutes of Health (NIH)-Funded Research
- More To Consider
- Key References
- For More Information
What’s the Bottom Line?
How much do we know about CoQ10?
We have some information from high quality studies done in people about the safety and effectiveness of CoQ10 for different conditions.
What do we know about the effectiveness of CoQ10?
CoQ10 supplements may benefit some patients with cardiovascular disorders, but research on other conditions is not conclusive.
What do we know about the safety of CoQ10?
CoQ10 has mild side effects and is generally well tolerated. However, it may make warfarin, an anticoagulant (blood thinner), less effective.
What Is CoQ10 and Why Is It Important?
Coenzyme Q10 (CoQ10) is an antioxidant that is necessary for cells to function properly. It is found in plants, bacteria, animals, and people. Cells use CoQ10 to make the energy they need to grow and stay healthy. CoQ10 can be found in highest amounts in the heart, liver, kidneys, and pancreas. Levels of CoQ10 decrease as you age.
- A variety of diseases, including some genetic disorders, are associated with low levels of CoQ10.
- Fish, meats, and whole grains all have small amounts of CoQ10, but not enough to significantly boost the levels in your body.
What the Science Says About Effectiveness of CoQ10
CoQ10 supplements may benefit some patients with cardiovascular disorders. Researchers have also looked at the effects of CoQ10 for drug-induced muscle weakness, reproductive disorders, cancer, and other diseases. However, results from these studies are limited and not conclusive.
The following information highlights the research status on CoQ10 for the conditions for which it has been studied.
- For patients with heart failure, taking CoQ10 was associated with improved heart function and also feeling better, according to research reviews published in 2007 and 2009. A 2013 meta-analysis also found an association between taking CoQ10 and improved heart function.
- Taking a combination of nutrients including CoQ10 was associated with quicker recovery after bypass and heart valve surgeries, according to a 2011 randomized controlled trial of 117 patients.
- For people with high blood pressure, the results of taking CoQ10 supplements have been mixed.
- Some studies suggest that CoQ10 is associated with blood pressure control, but the findings are limited, a 2009 systematic review showed.
- CoQ10 does not reduce high blood pressure or heart rate in patients with metabolic syndrome (a group of conditions that put you at risk for heart disease and diabetes), a small, randomized clinical trial reported in 2012.
Muscle Weakness From Statins (Cholesterol-lowering Drugs)
- A 2010 review described research showing that CoQ10 may help ease the myopathy (muscle weakness) sometimes associated with taking statins. However, the findings are not definite, the review concluded.
- A 2012 clinical trial of 76 patients who developed muscle pain within 60 days of starting statins found that CoQ10 was no better for pain than a placebo.
There is evidence that CoQ10 may improve semen quality and sperm count in infertile men, a 2010 review noted. However, it is uncertain whether this improvement affects the likelihood of conception.
There is no convincing evidence that CoQ10 prevents or treats cancer, but two large studies from 2010 and 2011 found that women who developed breast cancer were more likely than others to have abnormal CoQ10 levels, either very low or unusually high.
Other Research on CoQ10
Studies have examined CoQ10 for amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), Down syndrome, diabetes, Huntington’s disease, migraines, Parkinson’s disease, neuromuscular diseases, and age-related changes in cells and genes. The research on CoQ10 for these conditions is limited so we can’t draw conclusions about its effectiveness.
What the Science Says About Safety and Side Effects of CoQ10
- Studies have not reported serious side effects related to CoQ10 use.
- The most common side effects of CoQ10 include insomnia, increased liver enzymes, rashes, nausea, upper abdominal pain, dizziness, sensitivity to light, irritability, headaches, heartburn, and fatigue.
- CoQ10 should not be used by women who are pregnant or breastfeeding.
- Statins may lower the levels of CoQ10 in the blood. However, it is unclear what type of health effect this may have on an individual.
- CoQ10 may make warfarin, an anticoagulant (blood thinner), less effective.
National Institutes of Health (NIH)-Funded Research
NIH is currently sponsoring studies investigating the effects of CoQ10 on mild-to-moderate muscle pain in people who take statins, fertility in older women, and breast cancer treatments.
More To Consider
- Do not use CoQ10 supplements to replace a healthful diet or conventional medical care, or as a reason to postpone seeing a health care provider about a medical problem.
- If you are thinking about using a dietary supplement, first get information on it from reliable sources. Keep in mind that dietary supplements may interact with medications or other supplements and may contain ingredients not listed on the label. Your health care provider can advise you.
- If you are pregnant or nursing a child, or if you are considering giving a child a dietary supplement, it is especially important to consult your (or your child’s) health care provider.
- Look for published research studies on CoQ10 for the health condition that interests you.
- Tell all your health care providers about any complementary health approaches you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care. For tips about talking with your health care providers about complementary health approaches, see NCCIH’s Time to Talk campaign.
For More Information
The NCCIH Clearinghouse provides information on NCCIH and complementary health approaches, including publications and searches of Federal databases of scientific and medical literature. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners.
A service of the National Library of Medicine (NLM), PubMed® contains publication information and (in most cases) brief summaries of articles from scientific and medical journals.
NIH Clinical Research Trials and You
The National Institutes of Health (NIH) has created a Web site, NIH Clinical Research Trials and You, to help people learn about clinical trials, why they matter, and how to participate. The site includes questions and answers about clinical trials, guidance on how to find clinical trials through ClinicalTrials.gov and other resources, and stories about the personal experiences of clinical trial participants. Clinical trials are necessary to find better ways to prevent, diagnose, and treat diseases.
Research Portfolio Online Reporting Tools Expenditures & Results (RePORTER)
RePORTER is a database of information on federally funded scientific and medical research projects being conducted at research institutions.
To provide resources that help answer health questions, MedlinePlus (a service of the National Library of Medicine) brings together authoritative information from the National Institutes of Health as well as other Government agencies and health-related organizations.
- Bookstaver DA, Burkhalter NA, Hatzigeorgiou C. Effect of coenzyme Q10 supplementation on statin-induced myalgias. American Journal of Cardiology. 2012;110(4):526–529.
- Chai W, Cooney RV, Franke AA, et al. Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: the multiethnic cohort study. Cancer Epidemiology, Biomarkers & Prevention. 2010;19(9):2351–2356.
- Hidaka T, Fujii K, Funahashi I, et al. Safety assessment of coenzyme Q10 (CoQ10). BioFactors. 2008;32(1–4):199–208.
- Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database of Systematic Reviews. 2009;(4):CD007435. Accessed at www.cochranelibrary.com on December 31, 2013.
- Kumar A, Kaur H, Devi P, et al. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacology & Therapeutics. 2009;124(3):259–268.
- Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Nutrition. 2010;26(3):250–254.
- Mancuso M, Orsucci D, Volpi L, et al. Coenzyme Q10 in neuromuscular and neurodegenerative disorders. Current Drug Targets. 2010;11(1):111–121.
- Singh U, Devaraj S, Jialal I. Coenzyme Q10 supplementation and heart failure. Nutrition Reviews. 2007;65(6 Pt 1):286–293.
- Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatric Disease and Treatment. 2009;5:597–610.
- Tiano L, Busciglio J. Mitochondrial dysfunction and Down’s syndrome: is there a role for coenzyme Q(10)? BioFactors. 2011;37(5):386–392.
- Leong JY, van der Merwe J, Pepe S, et al. Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomized trial. Heart, Lung & Circulation. 2010;19(10):584–591.
- Marcoff L, Thompson PD. The role of coenzyme Q10 in statin-associated myopathy: a systematic review. Journal of the American College of Cardiology. 2007;49(23):2231–2237.
- McMurray JJ, Dunselman P, Wedel H, et al. Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure). Journal of the American College of Cardiology. 2010;56(15):1196–1204.
- National Cancer Institute. Coenzyme Q10 PDQ. National Cancer Institute Web site. Accessed at http://www.cancer.gov/cancertopics/pdq/cam/coenzymeQ10/patient on December 31, 2013.
- NINDS NET-PD Investigators. A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology. 2007;68(1):20–28.
- Quinzii CM, Hirano M. Primary and secondary CoQ(10) deficiencies in humans. BioFactors. 2011;37(5):361–365.
- Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. Archives of Neurology. 2007;64(7):938–944.
- Young JM, Florkowski CM, Molyneux SL, et al. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome. American Journal of Hypertension. 2012;25(2):261–270.
- Yubero-Serrano EM, Delgado-Casado N, Delgado-Lista J, et al. Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women. Age. 2011;33(4):579–590.
- Yubero-Serrano EM, Gonzalez-Guardia L, Rangel-Zuñiga O, et al. Mediterranean diet supplemented with coenzyme Q10 modifies the expression of proinflammatory and endoplasmic reticulum stress-related genes in elderly men and women. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2012;67(1):3–10.
NCCIH thanks the following people for their technical expertise and review of this publication: Ryan Bradley, N.D., M.P.H, Bastyr University; Paul Thompson, M.D., Hartford Hospital; Jeffrey D. White, M.D., National Cancer Institute; and John (Jack) Killen, Jr., M.D. and Wendy Weber, N.D., Ph.D., M.P.H., NCCIH.
This publication is not copyrighted and is in the public domain. Duplication is encouraged.