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Roundtable Meeting on Dietary Supplement–Drug Interactions Agenda


Tuesday, March 27, 2012
Neuroscience Building, 6001 Executive Blvd
Rockville, Maryland

8:30 a.m.

Welcome and Introduction

Josephine Briggs, M.D., National Center for Complementary and Alternative Medicine
Paul Coates, Ph.D., Office of Dietary Supplements
Jeffrey White, M.D., National Cancer Institute

8:50 a.m.

Overview of Workshop/Charge to Attendees

Craig Hopp, Ph.D., National Center for Complementary and Alternative Medicine

9:00 a.m.

Session I: Obstacles to Drug Interaction Research

Moderator: Craig Hopp, Ph.D., National Center for Complementary and Alternative Medicine

9:05 a.m.
Evaluation of Dietary Supplement–Drug Interactions: Limitations of In Vitro Methods
John Markowitz, Pharm.D., University of Florida
9:25 a.m.
Evaluating the Clinical Relevance of Human Dietary Supplement-Drug Interaction Study Designs
Bill Gurley, Ph.D., University of Arkansas
9:45 a.m.
Questions and Discussion
10:15 a.m.


10:30 a.m.

Session II: Roundtable Discussion on Improved Methodology

Moderator: Shiew-Mei Huang, Ph.D., U.S. Food and Drug Administration

  • Are there any computational, i.e. in silico, methods that can be employed?
  • Does high throughput screening offer any insight into possible clinical drug interactions?
  • How can we make animal models more predictive?
11:15 a.m.

Session III: Pharmacokinetic Interactions

Moderator: Joseph Betz, Ph.D., Office of Dietary Supplements

11:20 a.m.
Predicting and Interpreting Drug Interactions With Nutrients and Natural Products
David J. Greenblatt, M.D., Tufts University School of Medicine
11:40 a.m.
Transport-Mediated Dietary Supplement–Drug Interactions
Reginald Frye, Pharm.D., Ph.D., University of Florida
12:00 noon
12:00 noon


1:30 p.m.

Session IV: Pharmacodynamic Interactions

Moderator: Jeffrey White, M.D., National Cancer Institute

1:35 p.m.
Botanicals as Adjuvant for Cancer Chemoprevention
Chun-Su Yuan, M.D., Ph.D., University of Chicago
1:55 p.m.
Overcoming Therapeutic Resistance by Nutraceuticals
Fazlul Sarkar, Ph.D., Wayne State University
2:15 p.m.
2:45 p.m.


3:00 p.m.

Session V: Roundtable Discussion on the Path Forward

Besides grapefruit juice and St. John’s wort, are there other clinically significant adverse interactions?

  • How should supplement/drug interaction research be prioritized?
  • Where can NCCAM resources provide the greatest impact?
  • How can we best inform the medical community and patient population about the relative risk/benefit of any particular combination?
  • What types of research have the greatest potential to impact clinical practice?
4:00 p.m.



Reginald Frye, Pharm. D., Ph.D., FCCP
Associate Professor
Department of Pharmacotherapy and Translational Research
Associate Director
University of Florida Center for Pharmacogenomics
College of Pharmacy
University of Florida
Gainesville, FL
David J. Greenblatt, M.D.
Louis Lasagna Professor of Pharmacology and Experimental Therapeutics
Sackler School of Graduate Biomedical Sciences
Tufts University School of Medicine
Boston, MA
Bill Gurley, Ph.D.
Department of Pharmaceutical Sciences
College of Pharmacy
University of Arkansas for Medical Sciences
Little Rock, AR
Shiew-Mei Huang, Ph.D.
Deputy Director
Office of Clinical Pharmacology
Center for Drug Evaluation and Research
Food and Drug Administration
Silver Spring, MD
John Markowitz, Pharm.D.
Department of Pharmacotherapy and Translational Research
College of Pharmacy
University of Florida
Gainesville, FL
Mary Paine, Ph.D., R.Ph.
Assistant Professor
Department of Pharmacotherapy and Experimental Therapeutics
Eshelman School of Pharmacy
University of North Carolina at Chapel Hill
Chapel Hill, NC
Fazlul Sarkar, Ph.D.
Department of Cancer Biology
Karmanos Cancer Center
Wayne State University
Detroit, MI
Chun-Su Yuan, M.D., Ph.D.
Cyrus Tang Professor, Department of Anesthesia & Critical Care
Director, Tang Center for Herbal Medicine Research
Pritzker School of Medicine
University of Chicago
Chicago, IL

This page last modified February 12, 2015