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Workshop on Chronic Overlapping Pain Conditions

August 13, 2012 to August 14, 2012

Natcher Conference Center, NIH, Bethesda, MD

Event Description

The National Institute of Dental and Craniofacial Research and the National Institute of Neurological Disorders and Stroke, together with the NIH Pain Consortium, is sponsoring a workshop on Chronic Overlapping Pain Conditions, to be August 13 and 14, 2012 in the Natcher Conference Center, Building 45 on the NIH Campus in Bethesda, Maryland.

Chronic overlapping pain conditions represent a complex set of painful disorders that occur frequently in the population, lack a mechanistic understanding, and are in need of hypothesis-driven research efforts. This workshop will bring together researchers with expertise in various pain conditions and other expertise to discuss these conditions and to develop a forward-thinking research agenda. The workshop will focus on our current understanding of chronic overlapping pain conditions, their etiology, risk factors, mechanisms of disease, outcome measures, and diagnosis. It will be a two-day meeting with short presentations by panelists and extensive discussion periods. The workshop will be co-chaired by Daniel Clauw from the University of Michigan and Elizabeth Unger from the Centers for Disease Control and Prevention. 

The goal of the workshop is to develop a coordinated research strategy that addresses underlying etiology; the trajectory of disease; risk factors for onset, progression and reversal; and approaches for developing outcome measures and diagnosis of these conditions.

The meeting is open to the research community and free registration will occur on Monday morning at the door beginning at 8 am. The workshop will start at 8:30 am.


A Workshop on Chronic Overlapping Pain Conditions
August 13–14, 2012
Natcher Conference Center, Building 45
National Institutes of Health
Bethesda, Maryland

Day One

Monday, August 13, 2012

8:30 am

Introductions and Welcome

John Kusiak, Program Officer, NIDCR
Story Landis, Director, NINDS
Martha Somerman, Director, NIDCR
Workshop Co-chairs: Dan Clauw, Univ. of Michigan and Beth Unger, CDC
Guidance to the Workshop Members

Session 1: Overview and Epidemiology of Chronic Overlapping Pain Conditions

9–9:30 am

Overview of the meeting and chronic overlapping pain conditions

Dan Clauw, Univ. of Michigan

9:30–9:40 am


9:40–10 am

Epidemiology of vulvodynia and overlapping conditions

Barbara Reed, Univ. of Michigan

10–10:10 am


10:10–10:30 am

Epidemiologic approaches to pain progression: Lessons from migraine

Richard Lipton, Albert Einstein College of Medicine

10:30–10:40 am


10:40–11 am

Coffee Break

11–11:20 am

Overlapping pain conditions: Disparities and special populations

Carmen Green, Univ. of Michigan

11:20–11:30 am


11:30–11:50 am

The presence of multiple functional somatic syndromes may be a marker for a common pathogenesis

John Warren, Univ. of Maryland Medical School

11:50–noon pm


noon–12:30 pm

General Discussion

12:30–1:30 pm


(on your own)

Session 2: Risk Factors and Mechanisms of Disease

1:30–1:50 pm

Phenotypes/genotypes in common and specific to chronic overlapping pain conditions

Bill Maixner, Univ. of North Carolina

1:50–2 pm


2–2:20 pm

Understanding chronic overlapping pain conditions: Lessons learned from twin studies

Niloofar Afari, Univ. of California San Diego

2:20–2:30 pm


2:30–2:50 pm

Role of quantitative sensory testing in determining mechanisms of overlapping conditions

Eli Eliav, Univ. of Medicine and Dentistry of New Jersey

2:50–3 pm


3–3:20 pm

What has the CDC’s CFS program taught us about overlapping conditions?

Beth Unger, CDC

3:20–3:30 pm


3:30–4 pm

General Discussion

4–4:15 pm


4:15 pm

Patient/Advocate Forum:

Terrie Cowley, The TMJ Association
Kim McCleary, The CFIDS Association of america
William Norton, International Foundation for Functional Gastrointestinal Disorders
Christin Veasley, National Vulvodynia Association

4:45 pm

Summary and Adjourn for the day

Day Two

Tuesday, August 14, 2012

Session 3: Current and Future Research Issues

8:30–8:50 am

Patient reported outcomes: Which are most critical? Are new ones needed?

David Williams, Univ. of Michigan

8:50–9 am


9–9:20 am

What can we learn from the study of other complex disorders using a systems biology approach (cardiovascular and autonomic nervous systems)?

Daniel Beard, Medical College of Wisconsin

9:20–9:30 am


9:30–9:50 am

Large scale pain neuroimaging using the PAIN.LONI repository

Bruce Naliboff, Univ. of California Los Angeles

9:50–10 am


10–10:30 am

General Discussion


Coffee Break

Session 4: Breakout Groups

10:45 am

Guidance to the Breakout Groups

Co-chairs: Dan Clauw and Beth Unger

10:50–noon pm

Breakout Groups Meet

Room D: Approaches to standardize patient classification
Room B: Common mechanisms of disease
Room C1: Risk factors for trajectory of disease
Room C2: Development of research diagnostics and outcomes measures

Topics to be discussed by each group:
Identify challenges/opportunities to advancing each area
Identify new knowledge needed to go forward with each area
How to develop a consensus approach
What is feasible in 5 years/10 years?
How to advance training and workforce growth in each area

noon–1 pm


1–2 pm

Individual Reports from Breakout Groups

2–3:30 pm

Develop a consensus set of research recommendations addressing the 5 discussion topics

3:30 pm

Wrap-up and Closing Comments

John Kusiak, NIDCR
Story Landis, NINDS
Martha Somerman, NIDCR

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