National Center for Complementary and Integrative Health (NCCIH)

NIH…Turning Discovery Into Health

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St. John's Wort and Depression Clinical Trial Results

NIH-funded study shows that an extract of the herb St. John’s wort was no more effective for treating major depression of moderate severity than placebo.

For More Information

  • Hypericum Depression Trial Study Group. Effect of Hypericum perforatum (St. John's wort) in major depressive disorder: a randomized controlled trial. Journal of the American Medical Association. ; 287(14):1807–1814.