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National Center for Complementary and Integrative Health

Natural Products Clinical Trials Funding Opportunities

The following notices of funding opportunities (NOFOs) focus on natural products and target support of all phases of clinical intervention development. Natural products, also called nutritional approaches, include a variety of products, such as herbs (also known as botanicals), vitamins and minerals, and probiotics. 

The following categories are tied to the conceptual framework delineating the purpose of each stage of research. Investigation can be proposed at any stage along this continuum.

Basic

Notice of Special Interest (NOSI): Fundamental Science Research on Complementary and Integrative Health Approaches, Including Natural Products or Mind and Body Interventions

NIH Guide #: NOT-AT-24-041
Related Notice(s) or Announcement(s):
  • PA-20-185 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
  • PA-20-184 - Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
  • PA-20-183 - Research Project Grant (Parent R01 Clinical Trial Required)
  • PA-20-195 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
  • PA-20-196 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)
  • PA-20-194 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
Activity Code:

R01 Research Project Grant

R21 Exploratory/Developmental Research Grant

First Receipt Date:October 7, 2024
Expiration Date: October 18, 2027
Scientific/Research Contact(s):

Mechanistic and Translational

Notice of Special Interest (NOSI): Fundamental Science Research on Complementary and Integrative Health Approaches, Including Natural Products or Mind and Body Interventions

NIH Guide #: NOT-AT-24-041
Related Notice(s) or Announcement(s):
  • PA-20-185 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
  • PA-20-184 - Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
  • PA-20-183 - Research Project Grant (Parent R01 Clinical Trial Required)
  • PA-20-195 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
  • PA-20-196 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)
  • PA-20-194 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
Activity Code:

R01 Research Project Grant

R21 Exploratory/Developmental Research Grant

First Receipt Date:October 7, 2024
Expiration Date: October 18, 2027
Scientific/Research Contact(s):

NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)

NIH Guide #: 

PAR-24-124

Activity Code:R61/R33 Exploratory/Developmental  Phased Award
First Receipt Date:February 4, 2024
Expiration Date: November 14, 2026
Scientific/Research Contact(s):Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov

NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)

NIH Guide #: PAR-24-116
Activity Code:R33 Exploratory/Developmental Grants Phase II.
First Receipt Date:January 20, 2024
Expiration Date: November 14, 2026
Scientific/Research Contact(s):Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov

Intervention Refinement and Optimization

NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)

NIH Guide #: PAR-25-271
Activity Code:R01 Research Project Grant
First Receipt Date:May 23, 2025
Expiration Date: November 14, 2026
Scientific/Research Contact(s):

Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov

NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)

NIH Guide #: 

PAR-25-269

Activity Code:R61/R33 Exploratory/Developmental Phased Award
First Receipt Date:May 23, 2025
Expiration Date: November 14, 2026
Scientific/Research Contact(s):Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov

NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)

NIH Guide #: PAR-25-270
Activity Code:R33 Exploratory/Developmental Grants Phase II
First Receipt Date:May 23, 2025
Expiration Date: November 14, 2026
Scientific/Research Contact(s):Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov

Efficacy

Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)

NIH Guide #: PAR-25-268
Activity Code:R01 Research Project Grant
First Receipt Date:January 20, 2025
Expiration Date: November 18, 2026
Scientific/Research Contact(s):

Beda Jean-Francois, Ph.D.  
Email: beda.jean-francois@nih.gov 

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required)

NIH Guide #: PAR-24-312
Activity Code:UG3/UH3 Exploratory/Developmental Phased Award Cooperative Agreement
First Receipt Date:January 20, 2025
Expiration Date: July 15, 2026
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D., M.P.H. 
Email: weberwj@mail.nih.gov 

Natural Product Multi-Site Clinical Trial Data Coordinating Center (Collaborative U24 Clinical Trial Required)

NIH Guide #: PAR-24-313
Activity Code:U24 Resource-Related Research Projects – Cooperative Agreements
First Receipt Date:January 20, 2025
Expiration Date: July 15, 2026
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D., M.P.H. 
Email: weberwj@mail.nih.gov 

Effectiveness and Pragmatic Studies

Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)

NIH Guide #: PAR-25-268
Activity Code:R01 Research Project Grant
First Receipt Date:January 20, 2025
Expiration Date: November 18, 2026
Scientific/Research Contact(s):

Beda Jean-Francois, Ph.D.  
Email: beda.jean-francois@nih.gov 

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required)

NIH Guide #: PAR-24-312
Activity Code:UG3/UH3 Exploratory/Developmental Phased Award Cooperative Agreement
First Receipt Date:January 20, 2025
Expiration Date: July 15, 2026
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D., M.P.H. 
Email: weberwj@mail.nih.gov 

Natural Product Multi-Site Clinical Trial Data Coordinating Center (Collaborative U24 Clinical Trial Required)

NIH Guide #: PAR-24-313
Activity Code:U24 Resource-Related Research Projects – Cooperative Agreements
First Receipt Date:January 20, 2025
Expiration Date: July 15, 2026
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D., M.P.H. 
Email: weberwj@mail.nih.gov 

Dissemination and Implementation Research

Dissemination and Implementation Research in Health (R21 Clinical Trial Optional) 

NIH Guide #: PAR-25-143
Activity Code:R21 Exploratory/Developmental Research Grant
First Receipt Date:January 16, 2025
Expiration Date: January 8, 2028
Scientific/Research Contact(s):

Jennifer Baumgartner, Ph.D.
Email: jennifer.baumgartner@nih.gov

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

NIH Guide #: PAR-25-144
Activity Code:R01 Research Project Grant
First Receipt Date:January 5, 2025
Expiration Date: January 8, 2028
Scientific/Research Contact(s):

Jennifer Baumgartner, Ph.D.
Email: jennifer.baumgartner@nih.gov