National Center for Complementary and Integrative Health (NCCIH)
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Evidence-Based Medicine: Literature Reviews


When talking to your patients about complementary health approaches, you want to be able to answer the question: Is there any scientific evidence that this complementary product or practice works and is safe? The resources on this page will help inform you about what the science says (limited to the past 5 years).

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Acupuncture for Chronic Pain

Alzheimer's Disease / Dementia

Anxiety and Complementary Health Approaches

Attention-Deficit Hyperactivity Disorder (ADHD)

Benign Prostatic Hyperplasia and Complementary Health Practices

Chelation for Coronary Heart Disease

Chondroitin and Glucosamine

Depression 2

Dermatitis, Atopic, Acne, Impetigo, Psoriasis, Rosacea

Dimethyl Sulfoxide (DMSO) and Methylsulfonylmethane (MSM) for Osteoarthritis

Folic Acid and Pregnancy

Hepatitis C and Silymarin

Herb-Drug Interactions

Irritable Bowel Syndrome

Natural Products Marketed for Disease Prevention and Wellness

Omega-3 and Cardiovascular Diseases

Omega-3 Fatty Acids and Prostate Cancer

Pediatric Immunization Controversy

Post-Traumatic Stress Disorder

Safety and Complementary Therapies

Seasonal Affective Disorder

Seasonal Allergies

Seasonal Allergies (Allergic Rhinitis)

Spinal Manipulation and Low-Back Pain

St. John’s Wort and Depression

St. John’s Wort Herb-Drug Interactions

Substance Use Disorders

Traditional Chinese Medicine

Urinary Tract Infections and Complementary Health Practices

Zinc for Common Colds

This page last modified April 17, 2018