National Center for Complementary and Integrative Health (NCCIH)
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Natural Products and Pain: The search for novel nonopioid analgesics

February 06, 2019

NIH Campus, Natcher Bulding 45, Balcony B
45 Center Drive
Bethesda, MD 20892

Event Description

The goal of the workshop is to facilitate the identification of novel nonopioid natural products with efficacious and nonaddictive analgesic properties. The workshop will also discuss research barriers for the study of such natural products for pain treatment and management. The discussion will focus on how to identify promising leads based on traditional medicine; how to discover and identify active natural products; and how to characterize the mechanisms through which they act. The talks will be organized around promising known nonopioid classes of natural products from various sources and will walk through their discovery and challenges that have been encountered in their development. The workshop is targeted to researchers engaged in basic and mechanistic research in the fields of natural products and/or pain signaling. We hope that through this workshop we will provide novel and important contributions to the goal of finding solutions to the current pain and opioid crisis.

VIEW archived livestream of this event online:


8:30 a.m.

Opening Remarks

Helene Langevin, M.D., NCCIH
Emmeline Edwards, Ph.D., NCCIH

8:40 a.m.

Session One—Overview: How To Find the Needles in a Haystack?

Moderator: Craig Hopp, Ph.D., NCCIH

Cassandra Quave, Ph.D., Emory University School of Medicine: Nature’s Pharmacy: How To Find Natural Products for Pain Management?
David Julius, Ph.D., University of California, San Francisco: Animal Venoms: Evolving Combinatorial Peptide Libraries for Pain Research
Justin Du Bois, Ph.D., Stanford University: Natural Products as Tool Compounds and Therapeutic Leads
Panel Discussion
10:10 a.m.


10:25 a.m.

Session Two—The Science of Animal-Derived Natural Products

Moderator: Michael Oshinsky, Ph.D., NINDS

Mandë Holford, Ph.D., Hunter College: Snail venom, conotoxin, and pain
Justin Murray, Ph.D., Amgen: Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory Peptides
Ru-Rong Ji, Ph.D., Duke University School of Medicine: Fish Oil and Pain: Resolution of Pain by Fish Oil-Derived Specialized Proresolving Mediators (SPMs)
Panel Discussion
11:55 a.m.

Lunch Break

12:55 p.m.

Session Three—The Science of Plant-Based Natural Products and Supplements 

Moderator: Philip Sanderson, Ph.D., NCATS

Michael Iadarola Ph.D., NIH Clinical Center: A Cactus-Like Plant, Resiniferatoxin, and Pain Control
Laura Bohn Ph.D., The Scripps Research Institute: Plants, Conolidine and Pain
Yan Xu Ph.D., University of Pittsburgh: Cannabinoids and Glycinergic Modulation of Pain
Donna Hammond Ph.D., University of Iowa Carver College of Medicine: Nicotinamide Riboside, a Vitamin B3 Precursor of NAD+, and Persistent Pain
Panel Discussion
2:55 p.m.


3:10 p.m.  

Session Four—The Science of Microbial-Derived Natural Products 

Moderator: Wen Chen, Ph.D., NCCIH

Philippe Picaut, Ph.D., Ipsen Bioscience: The Science of Bacteria-Derived Natural Products—Botulinum Toxins
Isaac Chiu, Ph.D., Harvard Medical School: Bacterial Toxins and Pain: Anthrax Toxin as a Platform To Target Pain
David Klumpp, Ph.D., Northwestern University Feinberg School of Medicine: Pain Phenotypes and Therapeutic Potential of Bacteria in the Bladder
Panel Discussion
4:40 p.m.

Concluding Session: Discussion and Future Directions

Chaired by David Julius, Ph.D., UCSF

This page last modified July 01, 2019