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Tackling Pain at the National Institutes of Health: Updates From the Bench, the Clinic, and the New NIH Pain Research Center

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The National Center for Complementary and Integrative Health (NCCIH) Division of Intramural Research is convening a 2-day symposium to learn from and discuss with key stakeholders across the National Institutes of Health (NIH) the current state and future directions of the intramural pain research program and to highlight current collaborations and discuss future research within the Pain Research Center (PRC). Attendees will hear from NIH Institute, Center, and Office (ICO) leadership and clinical and basic researchers across NIH and will learn about ongoing projects and collaborations that are underway in the PRC.

The PRC, with support from the NIH Intramural Research Program (IRP) Director’s Challenge Award, various NIH ICOs, the Clinical Center, and other contributors and collaborators, serves as a hub for clinical pain research, creating and continuing to develop a pain phenotyping platform to better characterize and understand mechanisms of diverse pain states, and to further develop and test therapies to better manage or prevent the development of chronic pain and opioid abuse.

This meeting is NIH-only. Please register with your NIH email address.

Agenda

March 31–April 1, 2022

Day 1: March 31, 1:00–5:00 p.m. ET 
1:00 p.m.Welcome Address: What is the Pain Research Center (PRC)?              
Helene M. Langevin, M.D., NCCIH
1:10–2:10  p.m.

Institute, Center, and Office (ICO) Perspective on Current Gaps and Future Opportunities for Pain Research in the National Institutes of Health (NIH) Intramural Research Program (IRP) and PRC        
Moderated by David Shurtleff, Ph.D., NCCIH

5 minutes each:

  • Michael Gottesman, M.D. (OIR) 
  • Nina Schor, M.D., Ph.D. (NINDS)
  • Maryland Pao, M.D. (NIMH)
  • Janice Lee, D.D.S., M.D. (NIDCR)
  • Amy Newman, Ph.D. (NIDA)
  • William Dahut, M.D. (NCI)
  • George Koob, Ph.D. (NIAAA)
  • Shannon Zenk, Ph.D., M.P.H, R.N., F.A.A.N. (NINR) 
2:10–2:45 p.m.

Clinical Center (CC) Medical Units        
Moderated by Nick Madian, Ph.D., NCCIH

5 minutes each:

  • James Gilman, M.D. (NIH CC)
  • Ann Berger, M.S.N., M.D. (NIH CC)
  • Andrew Mannes, M.D., M.E., M.B.A. (NIH CC)
  • Jay Shah, M.D. (NIH CC)
  • Peter Herscovitch, M.D. (NIH CC)
2:45–3:00 p.m.Break
3:00–3:50 p.m.

Session 1: Studying Pain Mechanisms in Humans        
Moderated by Eleni Frangos, Ph.D., NCCIH

  • Miroslav “Misha” Backonja, M.D. (NCCIH). What clinical and experimental models of pain reveal about pain mechanisms
  • Lauren Atlas, Ph.D. (NCCIH/NIMH/NIDA). Evaluating behavioral, autonomic, and neural responses to acute pain in humans
  • Saad Nagi, Ph.D. (Linköping University). Pain in the ultrafast lane 
3:50–4:40 p.m.

Session 2: Studying Pain Mechanisms in Animal Models        
Moderated by Yogita Chudasama, Ph.D., NIMH 

  • Yarimar Carrasquillo, Ph.D. (NCCIH). Circuits and cells for pain modulation in the amygdala
  • Yuanyuan “Kevin” Liu, Ph.D. (NIDCR). Deciphering corticospinal circuits in controlling touch and tactile neuropathic pain sensitivity 
  • Yeka Aponte, Ph.D. (NIDA). Hypothalamic cell types and circuits that orchestrate pain behaviors in mice
4:40–5:00 p.m.

Roundtable: Bridging the Gap Between Animal and Human Studies        
Moderated by Eleni Frangos, Ph.D., NCCIH, and Yogita Chudasama, Ph.D., NIMH

  • All speakers from Sessions 1 and 2 will participate
5:00 p.m.Adjourn for the day  
Day 2: April 1, 1:00–4:15 p.m. ET 
1:00–1:05 p.m.Welcome Address        
David Shurtleff, Ph.D., NCCIH
1:05–1:30 p.m.Richard Nahin, Ph.D., M.P.H. (NCCIH). Populations at risk for developing chronic, disabling pain
1:30–3:40 p.m.

PRC Collaborative Project Presentations        
Moderated by Titilola Akintola, Ph.D., NCCIH

  • Matt Merguerian, M.D., Ph.D. (Johns Hopkins School of Medicine/ NHGRI). RUNX1 & pain: is there a clinical signal?
  • Carlos Zarate, M.D. (NIMH). Developing therapeutics for treatment-resistant depression and pain: a multimodal approach 
  • Deepika Darbari, M.D. (CNH, NHLBI) and Eleni Frangos, Ph.D. (NCCIH). Examining the pain phenotype of post-curative therapy sickle cell patients
  • Alison Boyce, M.D. (NIDCR). Pain phenotypes in patients with fibrous dysplasia 
2:30–2:40 p.m.Break
 

PRC Collaborative Project Presentations (continued)        
Moderated by Sudhuman Singh, Ph.D., NCCIH

  • Alex Chesler, Ph.D. (NCCIH) and Carsten Bönnemann, M.D. (NINDS). What a rare disease has taught us about touch and pain 
  • Ellen Staedtler, M.D., Ph.D. (NIH CC). Quantitative sensory testing (QST) in patients with Morton’s neuroma. A pilot study and collaboration between the Department of Perioperative Medicine and the Pain Research Center
  • Mike Iadarola, Ph.D. (NIH CC). The critical cells for pain and pain control
  • Leorey Saligan, Ph.D., R.N., C.R.N.P., F.A.A.N. (NINR). Advancing symptom science: phenotyping, pathobiology, and therapy
3:40–4:05 p.m.

Future Directions         
Participants: 

  • Miroslav “Misha” Backonja, M.D.
  • Eleni Frangos, Ph.D.
  • Lauren Atlas, Ph.D.
  • Alex Chesler, Ph.D.
4:05–4:15 p.m.Closing Remarks        
David Shurtleff, Ph.D., NCCIH
4:15 p.m.Adjourn

Speakers

Titilola Akintola, Ph.D. 
Visiting Postdoctoral Fellow 
Section on Affective Neuroscience and Pain 
National Center for Complementary and Integrative Health

Yeka Aponte, Ph.D. 
Chief, Neuronal Circuits and Behavior Unit 
Associate Director for Diversity and Inclusion 
National Institute on Drug Abuse

Lauren Atlas, Ph.D. 
Chief, Section on Affective Neuroscience and Pain 
National Center for Complementary and Integrative Health 
Joint faculty member at National Institute on Drug Abuse and National Institute of Mental Health

Miroslav “Misha” Backonja, M.D. 
Supervisory Clinician Physician 
National Center for Complementary and Integrative Health 

Ann Berger, M.S.N., M.D. 
Chief, Pain and Palliative Care Service
NIH Clinical Center 

Carsten G. Bönnemann, M.D., habil.
Chief, Neuromuscular and Neurogenetic Disorders of Childhood Section
Senior Investigator and Acting Chief, Neurogenetics Branch

Alison Boyce, M.D. 
Lasker Clinical Research Scholar 
Metabolic Bone Disorders Unit 
National Institute of Dental and Craniofacial Research

Yarimar Carrasquillo, Ph.D. 
Chief, Behavioral Neurocircuitry and Cellular Plasticity Section 
National Center for Complementary and Integrative Health

Alexander Chesler, Ph.D. 
Senior Investigator 
Sensory Cells and Circuits Section 
National Center for Complementary and Integrative Health
Joint faculty member at National Institute of Neurological Disorders and Stroke      

Yogita Chudasama, Ph.D. 
Chief, Section on Behavioral Neuroscience 
Director, Rodent Behavioral Core 
National Institute of Mental Health

William Dahut, M.D. 
Scientific Director for Clinical Research 
Center for Cancer Research 
National Cancer Institute

Deepika Darbari, M.D. 
Special Volunteer 
National Heart, Lung, and Blood Institute 
Attending Physician, Division of Hematology 
Children’s National Hospital

Eleni Frangos, Ph.D. 
Research Fellow 
Pain and Integrative Neuroscience Branch 
Pain Research Center 
National Center for Complementary and Integrative Health

James Gilman, M.D. 
Chief Executive Officer 
NIH Clinical Center

Michael Gottesman, M.D. 
Deputy Director for Intramural Research 
Office of Intramural Research

Peter Herscovitch, M.D. 
Chief, Positron Emission Tomography 
Senior Attending Physician 
NIH Clinical Center

Michael Iadarola, Ph.D. 
Senior Scientist 
Department of Perioperative Medicine, Anesthesia Section 
NIH Clinical Center

George Koob, Ph.D. 
Director 
National Institute on Alcohol Abuse and Alcoholism

Helene M. Langevin, M.D. 
Director 
National Center for Complementary and Integrative Health

Janice Lee, D.D.S., M.D., M.S. 
Clinical Director  
Chief, Cranial Anomalies & Regeneration Section 
National Institute of Dental and Craniofacial Research 
Deputy Director for Intramural Clinical Research 
Office of Intramural Research

Yuanyuan “Kevin” Liu, Ph.D. 
Chief, Somatosensation and Pain Unit 
National Institute of Dental and Craniofacial Research 
Joint faculty member at National Center for Complementary and Integrative Health

Nicholas Madian, Ph.D. 
Postdoctoral Fellow 
Pain and Integrative Neuroscience Branch 
Pain Research Center 
National Center for Complementary and Integrative Health

Andrew Mannes, M.D., M.E., M.B.A. 
Chief, Department of Perioperative Medicine 
NIH Clinical Center

Matt Merguerian, M.D., Ph.D. 
Special Volunteer
National Human Genome Research Institute
Instructor of Pediatrics, Division of Pediatric Hematology
Johns Hopkins University School of Medicine

Saad Nagi, Ph.D. 
Associate Professor in Neurophysiology 
Center for Social and Affective Neuroscience 
Linköping University

Richard Nahin, Ph.D., M.P.H. 
Lead Epidemiologist 
National Center for Complementary and Integrative Health

Amy Newman, Ph.D. 
Scientific Director, Intramural Program 
Chief, Molecular Targets and Medications Discovery Branch 
Chief, Medicinal Chemistry Section 
Director, Medication Development Program 
National Institute on Drug Abuse

Maryland Pao, M.D. 
Clinical Director and Deputy Scientific Director 
National Institute of Mental Health 
Acting Clinical Director 
National Center for Complementary and Integrative Health

Leorey Saligan, Ph.D., R.N., C.R.N.P., F.A.A.N. 
Acting Chief, Symptom Science Center 
Senior Investigator, Symptom Biology Unit 
National Institute of Nursing Research

Nina Schor, M.D., Ph.D. 
Deputy Director and Acting Scientific Director
National Institute of Neurological Disorders and Stroke

Jay Shah, M.D. 
Senior Staff Physiatrist and Clinical Investigator
Rehabilitation Medicine 
NIH Clinical Center

David Shurtleff, Ph.D. 
Deputy Director 
Acting Scientific Director 
Acting Chief, Clinical Investigations Branch 
Acting Chief, Pain and Integrative Neuroscience Branch 
National Center for Complementary and Integrative Health

Sudhuman Singh, Ph.D. 
Visiting Postdoctoral Fellow 
Section on Behavioral Neurocircuitry and Cellular Plasticity 
National Center for Complementary and Integrative Health

Ellen Staedtler, M.D., Ph.D. 
Postdoctoral Fellow 
Department of Perioperative Medicine 
NIH Clinical Center

Carlos Zarate, M.D. 
Chief, Experimental Therapeutics and Pathophysiology Branch 
National Institute of Mental Health

Shannon Zenk, Ph.D., M.P.H., R.N., F.A.A.N. 
Director 
National Institute of Nursing Research