Division of Intramural Research
Pain and Integrative Neuroscience Laboratory
The main goal of the lab is to identify anatomical, molecular, and cellular mechanisms that underlie pathological pain states. Research will focus on the amygdala, a structure in the limbic brain system that plays critical roles in the modulation of tactile hypersensitivity, pain-related aversion learning, and pain-induced changes in anxiety-related behaviors in rodent models of persistent pain.
Electrophysiological studies have demonstrated that increased excitability of amygdala neurons correlates with persistent pain, suggesting that hyperexcitability of neurons in the amygdala plays a critical role in the modulation of pain hypersensitivity. The specific conductance pathways affected and the molecular mechanisms underlying plasticity of the intrinsic excitability of amygdala neurons, however, are not known. In addition, the physiological role(s) of changes in the excitability of amygdala neurons to pain-related behaviors remain undefined. Research in the lab addresses these questions directly by combining behavioral, biochemical, electrophysiological, pharmacological and molecular genetic approaches.
Parallel studies in the lab use anatomical, behavioral, electrophysiological, and optogenetic approaches to define how alterations in the excitability of amygdala neurons affect function at a circuit-level. These studies focus on evaluating the physiological impact of the modulation of neuronal excitability in distinct anatomical pathways to and from the amygdala on different components of persistent pain, including the sensory, affective and cognitive components.