Pain Neurocircuitry and Cellular Plasticity Lab

Selected Publications:

• Wilson TD, Valdivia S, Khan A, Ahn H-S, Adke AP, Gonzalez SM, Sugimura YK, Carrasquillo Y. Dual and opposing functions of the central amygdala in the modulation of pain. Cell Reports. 2019;29(2):332-346.
• Adke AP, Khan A, Ahn H-S, Becker JJ, Wilson TD, Valdivia S, Sugimura YK, Gonzalez SM, Carrasquillo Y. Cell-type specificity of neuronal excitability and morphology in the central amygdala. eNeuro. 2021;8(1):ENEURO.0402-20-2020.
• Francis-Malavé AM, Martínez González S, Pichardo C, Wilson TD, Rivera-García LG, Brinster LR, Carrasquillo Y. Sex differences in pain-related behaviors and clinical progression of disease in mouse models of colonic pain.(external link) Pain. 2023;164(1):197-215.
• Singh S, Wilson TD, Valdivia S, Benowitz B, Chaudhry S, Ma J, Adke AP, Soler-Cedeño O, Velasquez D, Penzo MA, Carrasquillo Y. An inhibitory circuit from central amygdala to zona incerta drives pain-related behaviors in mice.(external link) Elife. 2022;11.
• Torres-Rodriguez JM, Wilson TD, Singh S, Torruella-Suarez ML, Chaudhry S, Adke AP, Becker JJ, Neugebauer B, Lin JL, Martinez Gonzalez S, Soler-Cedeño O, Carrasquillo Y. The parabrachial to central amygdala circuit is a key mediator of injury-induced pain sensitization. Neuropsychopharmacology. 2024;49(3):508-520.

Other Publications:

• Kiritoshi T, Yakhnitsa V, Singh S, Wilson TD, Chaudhry S, Neugebauer B, Torres-Rodriguez JM, Lin JL, Carrasquillo Y, Neugebauer V. Cells and circuits for amygdala neuroplasticity in the transition to chronic pain. Cell Reports. 2024;43(9):114669. 
• Rivera-García LG, Francis-Malavé AM, Castillo ZW, Uong CD, Wilson TD, Ferchmin PA, Eterovic V, Burton MD, Carrasquillo Y. Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco cembranoid in a mouse model of inflammatory pain. Journal of Inflammation. 2024;21(1):2.

• Torres-Rodriguez JM, Wilson TD, Singh S, Torruella-Suárez ML, Chaudhry S, Adke AP, Becker JJ, Neugebauer B, Lin JL, Martinez Gonzalez S, Soler-Cedeño O, Carrasquillo Y. The parabrachial to central amygdala pathway is critical to injury-induced pain sensitization in mice. Neuropsychopharmacology. 2024;49(3):508-520. 
• Torruella-Suárez ML, Neugebauer B, Flores-Felix K, Keller A, Carrasquillo Y, Cramer N. Divergent changes in PBN excitability in a mouse model of neuropathic pain. eNeuro. 2024;11(3):ENEURO.0416-23.2024.
• Kiritoshi T, Yakhnitsa V, Singh S, Wilson TD, Chaudhry S, Neugebauer B, Torres-Rodriguez JM, Lin JL, Carrasquillo Y, Neugebauer V. Cells and circuits for amygdala neuroplasticity in the transition to chronic pain. Cell Reports. 2024;43(9):114669. 
• Ransdell JL, Carrasquillo Y, Bosch MK, et al. Loss of intracellular fibroblast growth factor 14 (iFGF14) increases the excitability of mature hippocampal and cortical pyramidal neurons. bioRxiv. 2024;2024.05.04.592532. Preprint posted online.
• Francis-Malave AM, Martinez Gonzalez S, Pichardo C, Wilson TD, Rivera LG, Brinster LR, Carrasquillo Y. Sex differences in pain-related behaviors and clinical progression of disease in mouse models of visceral pain. bioRxiv. 2023;164(1):197-215.
• Allen HN, Chaudhry S, Hong VM, Lewter LA, Sinha GP, Carrasquillo Y, Taylor BK, Kolber BJ. A parabrachial-to-amygdala circuit that determines hemispheric lateralization of somatosensory processing. Biological Psychiatry. 2023;93(4):370-381. 
• Singh S, Wilson TD, Valdivia S, Benowitz B, Chaudhry S, Ma J, Adke AP, Soler-Cedeño O, Velasquez D, Penzo MA, Carrasquillo Y. An inhibitory circuit from central amygdala to zona incerta drives pain-related behaviors in mice. Elife. 2022;11:e68760.
• Rivera-García LG, Francis-Malavé AM, Wilson TD, Ferchmin PA, Eterovic V, Carrasquillo Y. 4R-Tobacco-cembranoid is a positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor that modulates inflammation-induced thermal hypersensitivity in mice. bioRxiv. Preprint posted online January 23, 2022. 
• Singh S, Valdivia S, Soler-Cedeño O, Adke AP, Benowitz B, Velasquez D, Wilson TD, Carrasquillo Y. Bidirectional modulation of pain-related behaviors in the zona incerta. bioRxiv. Preprint posted online March 12, 2021.
• Adke AP, Khan A, Ahn H-S., Becker JJ, Wilson TD, Valdivia S, Sugimura YK, Martinez Gonzalez S, Carrasquillo Y. Cell-type specificity of neuronal excitability and morphology in the central amygdala. eNeuro. 2021;8(1):ENEURO.0402-20.2020.
• Miller Neilan R, Majetic G, Gil-Silva M, Adke AP, Carrasquillo Y, Kolber BJ. Agent-based modeling of the central amygdala and pain using cell-type specific physiological parameters. PLoS Computational Biology. 2021;17(6):e1009097.
• Becker JJ, Carrasquillo Y. Projections, where art thou: the state and future of the central amygdala. The Journal of Physiology. 2019;597(2):365-366.
• Wilson TD, Valdivia S, Khan A, Ahn H-S, Adke AP, Martinez Gonzalez S, Sugimura YK, Carrasquillo Y. Dual and opposing functions of the central amygdala in the modulation of pain. Cell Reports. 2019;29(2):332-346.e5.
• Hermanstyne TO, Simms CL, Carrasquillo Y, Herzog ED, Nerbonne JM. Distinct firing properties of vasoactive intestinal peptide-expressing neurons in the suprachiasmatic nucleus. Journal of Biological Rhythms. 2016;31(1):57-67.
• Bosch MK, Carrasquillo Y, Ransdell JL, Kanakamedala A, Ornitz DM, Nerbonne JM. Intracellular FGF14 (iFGF14) is required for spontaneous and evoked firing in cerebellar Purkinje neurons and for motor coordination and balance. The Journal of Neuroscience. 2015;35(17):6752-6769.
• Granados-Fuentes D, Hermanstyne TO, Carrasquillo Y, Nerbonne JM, Herzog ED. IA channels encoded by Kv1.4 and Kv4.2 regulate circadian period of Per2 expression in the suprachiasmatic nucleus. Journal of Biological Rhythms. 2015;30(5):396-407.
• Carrasquillo Y, Nerbonne JM. IA channels: diverse regulatory mechanisms. The Neuroscientist. 2014;20(2):104-111.
• Yang W, Carrasquillo Y, Hooks BM, Nerbonne JM, Burkhalter A. Distinct balance of excitation and inhibition in an interareal feedforward and feedback circuit of mouse visual cortex. The Journal of Neuroscience. 2013;33(44):17373-17384.
• Carrasquillo Y, Burkhalter A, Nerbonne JM. A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability in cortical pyramidal neurons. The Journal of Physiology. 2012;590(16):3877-3890.
• Granados-Fuentes D, Norris AJ, Carrasquillo Y, Herzog E, Nerbonne JM. I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity. The Journal of Neuroscience. 2012;32(29):10045-10052.
• Marionneau C, Carrasquillo Y, Norris AJ, Townsend RR, Isom LL, Link AJ, Nerbonne JM. The sodium channel accessory subunit Nav?1 regulates neuronal excitability through modulation of repolarizing voltage-tated K+ channels. The Journal of Neuroscience. 2012;32(17):5716-5727.
• Kolber BJ, Montana MC, Carrasquillo Y, Xu J, Heinemann SF, Muglia LJ, Gereau IV RW. Activation of metabotropic glutamate receptor 5 in the amygdala modlates pain-like behavior. The Journal of Neuroscience. 2010;30(24):8203-8213.
• Carrasquillo Y, Gereau IV RW. Hemispheric lateralization of a molecular signal for pain modulation in the amygdala. Molecular Pain. 2008;4:24.
• Carrasquillo Y, Gereau IV RW. Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception. The Journal of Neuroscience. 2007;27(7):1543-1551.
• Hu H-J, Alter BJ, Carrasquillo Y, Qiu C-S, Gereau IV RW. Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. The Journal of Neuroscience. 2007;27(48):13181-13191.
• Hu H-J, Carrasquillo Y, Karim F, Jung WE, Nerbonne JM, Schwarz TL, Gereau IV RW. The Kv4.2 potassium channel subunit is required for pain plasticity. Neuron. 2006;50(1):89-100.
• Carrasquillo Y, Sweatt JD. Craving cocaine pERKs up the amygdala. Nature Neuroscience. 2005;8(2);129-130.
• Carrasquillo Y, Gereau IV RW. Rodent models clarify the role of cells expressing the substance P receptor in pain. Drug Discovery Today: Disease Models. 2004;1(2):107-113.

Full list of publications for Yarimar Carrasquillo, Ph.D. on PubMed.