Alexander (Alex) Chesler, Ph.D. heads the Section on Sensory Cells and Circuits. This lab is interested in the neurons and circuits of the somatosensory system and the changes that they undergo during injury and inflammation. Currently, research in the lab is focused on discovering new molecules involved in the transduction of somatosensory stimuli and studying the regions of the brain that encode innocuous versus painful stimuli. Our work centers on a class of sensory neurons (called C fibers) that encode thermal, noxious, and mechanical stimuli. To investigate these questions, we are using a variety of methods in the lab to study transgenic mice that include physiology, two-photon imaging, optogenetics, and behavior.